Two-dimensional supplies have attracted vital curiosity and investigation for the reason that marvellous discovery of graphene. On account of their distinctive bodily, mechanical and optical properties, van der Waals (vdW) supplies possess extraordinary potential for software in future optoelectronics gadgets. Nano-engineering and nano-manufacturing within the atomically skinny regime has additional opened multifarious avenues to discover novel bodily properties. Amongst them, moiré heterostructures, pressure engineering and substrate manipulation have created quite a few unique and topological phenomena reminiscent of unconventional superconductivity, orbital magnetism, versatile nanoelectronics and extremely environment friendly photovoltaics. This evaluate comprehensively summarizes the three most influential strategies of nano-engineering in 2D supplies. The most recent improvement within the marvels of moiré buildings in vdW supplies is mentioned; as well as, topological buildings in layered supplies and substrate engineering on the nanoscale are completely scrutinized to spotlight their significance in micro- and nano-devices. Lastly, we conclude with remarks on challenges and attainable future instructions within the quickly increasing discipline of nanotechnology and nanomaterial.